General Health Tips & News

The Role of Vitamin K Supplements in Heart Patients

By A.S. (staff writer) , published on May 16, 2023

Medicine Telehealth Health




Heart disease remains one of the leading causes of death globally, and managing risk factors for heart disease is crucial in preventing its onset and progression. Diet and nutrition play a significant role in cardiovascular health, and emerging research has shed light on the potential benefits of vitamin K supplements in heart patients. Vitamin K, a fat-soluble vitamin, is known for its role in blood clotting, but recent studies have also revealed its potential cardiovascular effects. In this article, we will explore the role of vitamin K supplements in heart patients, examining the current research and understanding the potential benefits and risks.


Understanding Vitamin K

Vitamin K is classified into two main forms: vitamin K1 (phylloquinone), found in leafy green vegetables, and vitamin K2 (menaquinone), synthesized by bacteria in the gut and found in animal-based and fermented foods. Vitamin K1 is involved in blood clotting and is essential for the synthesis of clotting factors in the liver. On the other hand, vitamin K2 is believed to have a role in calcium metabolism and is associated with cardiovascular health.


Vitamin K and Cardiovascular Health

Several studies have investigated the potential benefits of vitamin K supplements in heart patients. One major area of research is the role of vitamin K in preventing arterial calcification, a process that contributes to atherosclerosis, the buildup of plaque in arteries that can lead to heart disease. Vitamin K2 has been shown to activate a protein called matrix Gla protein (MGP), which helps prevent calcium from depositing in arterial walls, reducing the risk of arterial calcification. This suggests that vitamin K2 may have a protective effect on cardiovascular health by keeping arteries healthy and preventing the development of atherosclerosis.

Furthermore, vitamin K2 has also been implicated in improving vascular elasticity, which refers to the ability of blood vessels to stretch and recoil in response to changes in blood flow. Loss of vascular elasticity is associated with arterial stiffness, which is an independent risk factor for cardiovascular disease. Vitamin K2 has been shown to activate proteins that promote vascular elasticity and reduce arterial stiffness, which may contribute to its potential cardiovascular benefits.



Emerging Research on Vitamin K Supplements and Heart Health

Several observational studies have also reported an association between higher vitamin K2 intake and a reduced risk of cardiovascular disease. For example, a study published in the journal Atherosclerosis found that higher vitamin K2 intake was associated with a lower risk of coronary artery calcification and reduced incidence of cardiovascular events in postmenopausal women. Another study published in the Journal of Nutrition reported that higher dietary intake of vitamin K2 was associated with a reduced risk of death from cardiovascular disease in a Dutch population.

However, it's important to note that most of the evidence supporting the cardiovascular benefits of vitamin K supplements comes from observational studies, which cannot establish causation and are subject to various biases. Further research, including randomized controlled trials, is needed to establish a cause-and-effect relationship between vitamin K supplementation and cardiovascular health.


Potential Interactions with Blood-Thinning Medications

In addition to its potential benefits, vitamin K supplements also come with potential risks, particularly for heart patients who are on blood-thinning medications, such as warfarin. Warfarin works by inhibiting the activity of vitamin K, and excessive vitamin K intake can interfere with the effectiveness of warfarin, leading to an increased risk of blood clotting or bleeding. Therefore, heart patients who are on blood-thinning medications should consult their healthcare provider before taking vitamin K supplements to avoid any potential interactions.


Optimal Dose

The optimal dosage of vitamin K supplements for heart patients is not yet established, and there is currently no recommended daily allowance (RDA) for vitamin K2. However, some studies suggest that a daily intake of 45-180 micrograms of vitamin K2 may be beneficial for cardiovascular health. Vitamin K2 supplements are available in various forms, such as MK-4 and MK-7, with MK -7 being the most common and well-studied form. It's important to choose a reputable brand and follow the dosing instructions on the product label or as recommended by a healthcare provider.



Importance of a Balanced Diet and Lifestyle Factors

It's worth mentioning that obtaining vitamin K through a balanced diet is generally considered safe, and there are no known risks associated with consuming vitamin K-rich foods, such as leafy green vegetables, fermented foods, and animal-based products. In fact, a healthy and balanced diet that includes a variety of foods rich in essential nutrients, including vitamin K, is always recommended for overall cardiovascular health.

In conclusion, emerging research suggests that vitamin K supplements, particularly vitamin K2, may have a role in promoting cardiovascular health by preventing arterial calcification and improving vascular elasticity. However, more research is needed to establish a definitive cause-and-effect relationship between vitamin K supplementation and cardiovascular outcomes. It's also important to note that vitamin K supplements may interact with blood-thinning medications and should be used with caution, especially in heart patients who are on such medications. Therefore, it's crucial to consult a healthcare provider before starting any vitamin K supplements or making significant changes to one's diet or supplementation routine.

As with any dietary supplement, it's important to choose a reputable brand, follow dosing instructions, and consider individual health needs and potential interactions with other medications. A well-balanced diet that includes a variety of nutrient-rich foods, including those naturally high in vitamin K, is always the best approach to promoting cardiovascular health




  1. Geleijnse JM, Vermeer C, Grobbee DE, et al. Dietary Intake of Menaquinone Is Associated with a Reduced Risk of Coronary Heart Disease: The Rotterdam Study. J Nutr. 2004;134(11):3100-3105.

  2. Beulens JW, Bots ML, Atsma F, et al. High dietary menaquinone intake is associated with reduced coronary calcification. Atherosclerosis. 2009;203(2):489-493.

  3. Shea MK, Holden RM. Vitamin K status and vascular calcification: evidence from observational and clinical studies. Adv Nutr. 2012;3(2):158-165.



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